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Standard Name


Gene Synonym(s)

ECK0115, b0116, JW0112, dhl, lpdA[1], lpdA

Product Desc.


Component of E3-CPLX[2]; lipoamide dehydrogenase[3]; 2-oxoglutarate dehydrogenase complex[2][3]; gcv system[2][3]; pyruvate dehydrogenase multienzyme complex[2][3]

Lipoamide dehydrogenase, NADH-dependent; E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes; also functions as glycine cleavage system L protein; binds Zn(II)[4]

Product Synonyms(s)

lipoamide dehydrogenase, E3 component is part of three enzyme complexes[1], B0116[2][1], Lpd[2][1], Dhl[2][1], LpdA[2][1] , dhl, ECK0115, JW0112, lpdA, b0116

Function from GO

Cellular Component

Molecular Function

Biological Process

Knock-Out Phenotype

transcription unit(s): lpdA[2], pdhR-aceEF-lpdA[2]

Quick Links

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Holoenzyme is AceE(24)+AceF(24)+Lpd(12). HT_Cmplx3_Cyt: AceF+Lpd.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.