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Standard Name


Gene Synonym(s)

ECK4336, b4346, JW5871, rglB[1], rglB

Product Desc.

McrB subunit of 5-methylcytosine restriction system[2][3];

Component of McrBC restriction endonuclease[3]

McrBC restriction endonuclease, catalytic subunit; 5-methylcytosine-specific; requires GTP, inhibited by ATP[4]

Product Synonyms(s)

5-methylcytosine-specific restriction enzyme McrBC, subunit McrB[1], B4346[2][1], RglB[2][1], McrB[2][1] , ECK4336, JW5871, rglB, b4346

Function from GO

Molecular Function

Biological Process

Knock-Out Phenotype

transcription unit(s): mcrBC[2]

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McrB-S is an alternative product initiating at codon 162. McrB-S is seen in some overexpression constructs but has not yet been observed as a native protein. McrB-S has no known function.[4]

In vitro, purified McrBs modulates the cleavage activity of McrBC, probably through binding to McrC.[5],


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Panne, D et al. (1998) McrBs, a modulator peptide for McrBC activity. EMBO J. 17 5477-83 PubMed EcoliWiki page