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metB:Gene Product(s)
From EcoliWiki
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
| Standard name |
MetB |
|---|---|
| Synonyms |
cystathionine gamma-synthase, PLP-dependent[1], B3939[2][1], MetB[2][1] |
| Product description |
Component of ; O-SUCCHOMOSERLYASE-CPLX[2] |
| EC number (for enzymes) | |
| edit table |
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0003962 |
cystathionine gamma-synthase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0006520 |
amino acid metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0008652 |
amino acid biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0009086 |
methionine biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0030170 |
pyridoxal phosphate binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0009063 |
amino acid catabolic process |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| edit table |
Interactions
| Partner Type | Partner | Notes | References |
|---|---|---|---|
|
Protein |
Subunits of O-SUCCHOMOSERLYASE-CPLX |
could be indirect |
|
| edit table |
See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Notes
metB1 is a mutant brought about by X-ray mutagenesis and is most likely a deletion mutation.
The metB1 mutation causes a requirement for methionine and produces no enzymatic activity. [6]
Localization
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
| edit table |
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Notes
Structure and Physical Properties
Physical Properties
| Sequence |
MTRKQATIAV RSGLNDDEQY GCVVPPIHLS STYNFTGFNE PRAHDYSRRG NPTRDVVQRA LAELEGGAGA VLTNTGMSAI HLVTTVFLKP GDLLVAPHDC YGGSYRLFDS LAKRGCYRVL FVDQGDEQAL RAALAEKPKL VLVESPSNPL LRVVDIAKIC HLAREVGAVS VVDNTFLSPA LQNPLALGAD LVLHSCTKYL NGHSDVVAGV VIAKDPDVVT ELAWWANNIG VTGGAFDSYL LLRGLRTLVP RMELAQRNAQ AIVKYLQTQP LVKKLYHPSL PENQGHEIAA RQQKGFGAML SFELDGDEQT LRRFLGGLSL FTLAESLGGV ESLISHAATM THAGMAPEAR AAAGISETLL RISTGIEDGE DLIADLENGF RAANKG |
|---|---|
| Mol. Wt |
41.55 kDa (calc) [2] |
| pI |
6.43[2] |
| Extinction coefficient |
25900 - 26525 (calc based on 10 Y, 2 W, and 5 C residues) |
| edit table |
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Domains/Motifs/Modification Sites
| Type | Residues | Description | Notes |
|---|---|---|---|
| edit table |
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
Structure
| Structures |
|
|---|---|
| Models |
View models at: |
| edit table |
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
Notes
Gene Product Resources
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Notes
Accessions in Other Databases
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
See Help:Product_accessions for help entering or editing information in this section of EcoliWiki.
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Hall BG (1989) Selection, adaptation, and bacterial operons. Genome 31: 265-71 PubMed EcoliWiki page
Categories
Categories: GO:0005515 ! protein binding | GO:0003824 ! catalytic activity | GO:0003962 ! cystathionine gamma-synthase activity | GO:0005737 ! cytoplasm | GO:0006520 ! amino acid metabolic process | GO:0008652 ! amino acid biosynthetic process | GO:0009086 ! methionine biosynthetic process | GO:0016740 ! transferase activity | GO:0030170 ! pyridoxal phosphate binding | GO:0009063 ! amino acid catabolic process | Proteins | Complex:O-SUCCHOMOSERLYASE-CPLX
