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Standard Name


Gene Synonym(s)

ECK0211, b0211, JW5018, dniR, yafG[1], yafG

Product Desc.

membrane-bound lytic murein transglycosylase D[2]; MltD membrane-bound lytic murein transglycosylase D[3]

Membrane-bound lytic transglycosylase D, murein hydrolase; periplasmic OM-attached lipoprotein[4]

Product Synonyms(s)

predicted membrane-bound lytic murein transglycosylase D[1], B0211[2][1], YafG[2][1], MltD[2][1], DniR[2][1] , dniR, ECK0211, JW5018, yafG, b0211

Function from GO

Biological Process

Molecular Function

Cellular Component

Knock-Out Phenotype

transcription unit(s): mltD[2]

Quick Links

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MltD has been shown to be a murein hydrolase using zymography, to cause lysis or osmotically-stabilized spheroplasts when overproduced, and to be inhibited by bulgecin (Dijkstra A.J., Rudd, K.E., and Keck, W., A new member of the transglycosylase family of Escherichia coli displays a Gram-positive hydrolase motif, in "The soluble lytic transglycolsylase family of Escherichia coli", A.J. Dijkstra, pp. 85-101, Ph.D. thesis, University of Groningen, the Netherlands,1997). MltD has two Gram-positive peptidoglycan-binding motifs in the C-terminus. MltD has a central lysozyme-like domain. MltD should cleave the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. First 15 aa are a type II signal peptide. The proposed DniR function as a regulator of hexaheme nitrite reductase is probably artifactual.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.