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mprA:Gene Product(s)
From EcoliWiki
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
MprA |
|---|---|
| Synonyms |
DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux[1], B2684[2][1], MprA[2][1], EmrR[2][1] |
| Product description |
EmrR transcriptional repressor[2]; MprA transcriptional repressor[3] emrAB repressor, also regulates microcin synthesis; binds uncouplers DNP, CCCP, FCCP[4] |
| EC number (for enzymes) |
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| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006350 |
transcription |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0006350 |
transcription |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0016564 |
transcription repressor activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0016564 |
transcription repressor activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0003700 |
transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [8] |
complete | |||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [8] |
complete | |||
| GO:0006350 |
transcription |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [8] |
complete | |||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0046677 |
response to antibiotic |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0046678 |
response to bacteriocin |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0005737 |
cytoplasm |
C |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
|
Protein |
Experiment(s):EBI-1143661 | |||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Source | Notes |
|---|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MDSSFTPIEQ MLKFRASRHE DFPYQEILLT RLCMHMQSKL LENRNKMLKA QGINETLFMA LITLESQENH SIQPSELSCA LGSSRTNATR IADELEKRGW IERRESDNDR RCLHLQLTEK GHEFLREVLP PQHNCLHQLW SALSTTEKDQ LEQITRKLLS RLDQMEQDGV VLEAMS |
|---|---|
| Length |
176 |
| Mol. Wt |
20.563 kDa |
| pI |
6.2 (calculated) |
| Extinction coefficient |
12,490 - 12,990 (calc based on 1 Y, 2 W, and 4 C residues) |
| edit table |
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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
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Structure
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Structure figures
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| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Brooun A et al. (1999) Purification and ligand binding of EmrR, a regulator of a multidrug transporter. J Bacteriol 181: 5131-3 PubMed EcoliWiki page
- ↑ 6.0 6.1 6.2 6.3 6.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 7.0 7.1 Xiong A et al. (2000) The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region. Antimicrob Agents Chemother 44: 2905-7 PubMed EcoliWiki page
- ↑ 8.0 8.1 8.2 8.3 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
