mreB:Gene Product(s)

Standard name	MreB
Synonyms	cell wall structural complex MreBCD, actin-like component MreB^[1], B3251^[2]^[1], RodY^[2]^[1], Mon^[2]^[1], EnvB^[2]^[1], MreB_1^[2]^[1], MreB^[2]^[1]
Product description	MreB^[2]^[3]; Component of longitudinal peptidoglycan synthesis/chromosome segregation-directing complex^[3] MreB filaments participate in directional chromosome movement and segregation; mecillinam resistance; forms membrane-associated coiled arrays; actin homolog; morphology^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000902	cell morphogenesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004753	P	Seeded from EcoCyc ^[5]	complete
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001023	F	Seeded from EcoCyc ^[5]	complete
	GO:0008360	regulation of cell shape	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0133	P	Seeded from EcoCyc ^[5]	complete
	GO:0042493	response to drug				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0000910	cytokinesis				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0051983	regulation of chromosome segregation	PMID:19187760^[6]	IGI: Inferred from Genetic Interaction	EcoliWiki:mreC\|EcoliWiki:mreD	P		complete
	GO:0051983	regulation of chromosome segregation	PMID:14517265^[7]	IMP: Inferred from Mutant Phenotype		P		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of longitudinal peptidoglycan synthesis/chromosome segregation-directing complex	could be indirect
Protein	accA		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	add		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	atpD		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	clpB		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	dnaK		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-893751
Protein	fusA		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	gatY		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	glyQ		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	gyrA		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-884206
Protein	kefC		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	lysU		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	malK		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	malT		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-879887
Protein	minD		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	groL		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-893751
Protein	narG		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-880367
Protein	nuoC		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	ompA		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	ompC		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	pnp		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-883913
Protein	pstB		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-878876
Protein	recA		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	rho		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	rplE		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	rpoB		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	rpoC		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	secA		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-880477, EBI-893751
Protein	radA		PMID:15690043^[8]	Experiment(s):EBI-888239
Protein	tufA		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-889981, EBI-893751
Protein	yleA		PMID:15690043^[8]	Experiment(s):EBI-888239, EBI-879008
Protein	ydiH		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	gatB		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	rplC		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	rpsF		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	uspG		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	ybeD		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	yjgD		PMID:15690043^[8]	Experiment(s):EBI-893751
Protein	ParC		PMID:19187760^[6]
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Source	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MVGKVSGFSF PPQLSGLSLS MLKKFRGMFS NDLSIDLGTA NTLIYVKGQG IVLNEPSVVA IRQDRAGSPK SVAAVGHDAK QMLGRTPGNI AAIRPMKDGV IADFFVTEKM LQHFIKQVHS NSFMRPSPRV LVCVPVGATQ VERRAIRESA QGAGAREVFL IEEPMAAAIG AGLPVSEATG SMVVDIGGGT TEVAVISLNG VVYSSSVRIG GDRFDEAIIN YVRRNYGSLI GEATAERIKH EIGSAYPGDE VREIEVRGRN LAEGVPRGFT LNSNEILEAL QEPLTGIVSA VMVALEQCPP ELASDISERG MVLTGGGALL RNLDRLLMEE TGIPVVVAED PLTCVARGGG KALEMIDMHG GDLFSEE
Length	367
Mol. Wt	38.972 kDa
pI	5.2 (calculated)
Extinction coefficient	7,450 - 7,825 (calc based on 5 Y, W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

View the PDB Table for mreB

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:EG10608-MONOMER
SwissModel (EcoliWiki Page)	SwissModel:P0A9X4
UniProt (EcoliWiki Page)	UniProt:P0A9X4
PFAM (EcoliWiki Page)	PFAM:PF06723
RefSeq (EcoliWiki Page)	RefSeq:NP_417717
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^6.0 ^6.1 Madabhushi R & Marians KJ (2009) Actin homolog MreB affects chromosome segregation by regulating topoisomerase IV in Escherichia coli. Mol Cell 33: 171-80 PubMed EcoliWiki page
↑ Kruse T et al. (2003) Dysfunctional MreB inhibits chromosome segregation in Escherichia coli. EMBO J 22: 5283-92 PubMed EcoliWiki page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 ^8.16 ^8.17 ^8.18 ^8.19 ^8.20 ^8.21 ^8.22 ^8.23 ^8.24 ^8.25 ^8.26 ^8.27 ^8.28 ^8.29 ^8.30 ^8.31 ^8.32 ^8.33 ^8.34 ^8.35 ^8.36 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page

mreB:Gene Product(s)

From EcoliWiki

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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