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References Suggestions

Standard Name


Gene Synonym(s)

ECK4166, b4170, JW4128[1], JW4128

Product Desc.


Component of MutHLS complex, methyl-directed mismatch repair[2][3]

Methyl-directed mismatch repair; matchmaker protein; weak DNA-stimulated ATPase[4]

Product Synonyms(s)

methyl-directed mismatch repair protein[1], B4170[2][1], MutL[2][1] , ECK4166, JW4128, b4170

Function from GO

Biological Process

Molecular Function

Cellular Component

Knock-Out Phenotype

transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC

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MutL DNA-binding is required for methyl-directed mismatch repair (Robertson, 2006). The ATPase activity of MutL is essential for mismatch repair (Ban, 1998; Ban, 1999; Spampinato, 2000; Robertson, 2006). MutL binds UvrD, stimulates UvrD unwinding activity and is required for UvrD loading onto DNA (Hall, 1998; Yamaguchi, 1998; Mechanic, 2000). MutL stimulates MutS and Vsr binding to mismatched DNA (Drotschmann, 1998).[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.