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Standard Name


Gene Synonym(s)

ECK3973, b3982, JW3945[1], JW3945

Product Desc.

transcription termination factor NusG[2][3]

Stabilizes phage lambda protein N-NusA-RNAP antitermination complex[4]

Product Synonyms(s)

transcription termination factor[1], B3982[2][1], NusG[2][1] , ECK3973, JW3945, b3982

Function from GO
Knock-Out Phenotype

transcription unit(s): secE-nusG[2]

Quick Links

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Binds TrxA (Kumar, 2004).[4]

Binds Rho [5]

Required for Rho-dependent termination in vivo [6] and enhances Rho-dependent termination in vitro [7] [8] [9]

Maintains genomic integrity [10]

Essential in rac+ strains to prevent expression of toxic prophage gene kilR [11]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Li, J et al. (1993) Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription. Genes Dev. 7 161-72 PubMed EcoliWiki page
  6. Sullivan, SL & Gottesman, ME (1992) Requirement for E. coli NusG protein in factor-dependent transcription termination. Cell 68 989-94 PubMed EcoliWiki page
  7. Nehrke, KW & Platt, T (1994) A quaternary transcription termination complex. Reciprocal stabilization by Rho factor and NusG protein. J. Mol. Biol. 243 830-9 PubMed EcoliWiki page
  8. Burns, CM & Richardson, JP (1995) NusG is required to overcome a kinetic limitation to Rho function at an intragenic terminator. Proc. Natl. Acad. Sci. U.S.A. 92 4738-42 PubMed EcoliWiki page
  9. Washburn, RS et al. (1996) The mechanism of early transcription termination by Rho026. J. Mol. Biol. 260 347-58 PubMed EcoliWiki page
  10. Washburn, RS & Gottesman, ME (2011) Transcription termination maintains chromosome integrity. Proc. Natl. Acad. Sci. U.S.A. 108 792-7 PubMed EcoliWiki page
  11. Cardinale, CJ et al. (2008) Termination factor Rho and its cofactors NusA and NusG silence foreign DNA in E. coli. Science 320 935-8 PubMed EcoliWiki page