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pepB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PepB

Synonyms

aminopeptidase B[1], B2523[2][1], YfhI[2][1], PepB[2][1] , ECK2520, JW2507, yfhI, b2523

Product description

aminopeptidase B[2][3]

Peptidase B; broad specificity aminopeptidase[4]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004177

aminopeptidase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00504

F

Seeded from EcoCyc (v14.0)

complete

GO:0004177

aminopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000819

F

Seeded from EcoCyc (v14.0)

complete

GO:0004177

aminopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008330

F

Seeded from EcoCyc (v14.0)

complete

GO:0004177

aminopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011356

F

Seeded from EcoCyc (v14.0)

complete

GO:0004177

aminopeptidase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0031

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006508

proteolysis

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00504

P

Seeded from EcoCyc (v14.0)

complete

GO:0006508

proteolysis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000819

P

Seeded from EcoCyc (v14.0)

complete

GO:0008233

peptidase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc (v14.0)

complete

GO:0008235

metalloexopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008330

F

Seeded from EcoCyc (v14.0)

complete

GO:0008235

metalloexopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011356

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0019538

protein metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011356

P

Seeded from EcoCyc (v14.0)

complete

GO:0030145

manganese ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00504

F

Seeded from EcoCyc (v14.0)

complete

GO:0030145

manganese ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008330

F

Seeded from EcoCyc (v14.0)

complete

GO:0030145

manganese ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011356

F

Seeded from EcoCyc (v14.0)

complete

GO:0030145

manganese ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0464

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

GO:0043171

peptide catabolic process

PMID:355237[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:pepA EcoliWiki:pepD EcoliWiki:pepN EcoliWiki:pepQ


P

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

fabH

PMID:15690043[7]

Experiment(s):EBI-887087

Protein

ompA

PMID:15690043[7]

Experiment(s):EBI-887087

Protein

helD

PMID:16606699[8]

Experiment(s):EBI-1143110

Protein

ompA

PMID:19402753[9]

MALDI(Z-score):36.958178

Protein

pepA

PMID:19402753[9]

LCMS(ID Probability):85.5 MALDI(Z-score):36.477008

Protein

fabH

PMID:19402753[9]

MALDI(Z-score):18.174763

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MPPSCNANHL AEKSWGCQLA ALLQRRITKM TEAMKITLST QPADARWGEK ATYSINNDGI
TLHLNGADDL GLIQRAARKI DGLGIKHVQL SGEGWDADRC WAFWQGYKAP KGTRKVVWPD
LDDAQRQELD NRLMIIDWVR DTINAPAEEL GPSQLAQRAV DLISNVAGDR VTYRITKGED
LREQGYMGLH TVGRGSERSP VLLALDYNPT GDKEAPVYAC LVGKGITFDS GGYSIKQTAF
MDSMKSDMGG AATVTGALAF AITRGLNKRV KLFLCCADNL ISGNAFKLGD IITYRNGKKV
EVMNTDAEGR LVLADGLIDA SAQKPEMIID AATLTGAAKT ALGNDYHALF SFDDALAGRL
LASAAQENEP FWRLPLAEFH RSQLPSNFAE LNNTGSAAYP AGASTAAGFL SHFVENYQQG
WLHIDCSATY RKAPVEQWSA GATGLGVRTI ANLLTA
Length

456

Mol. Wt

49.401 kDa

pI

6.5 (calculated)

Extinction coefficient

72,880 - 73,755 (calc based on 12 Y, 10 W, and 7 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

107..423

PF00883 Cytosol aminopeptidase family, catalytic domain

PMID:19920124[10]

Domain

5..81

PF12404 Peptidase

PMID:19920124[10]


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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

No results found for a best structure.

Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111453

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948766

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008305

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P37095

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12310

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12310

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948766

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002187

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2216

Escherichia coli str. K-12 substr. MG1655

Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed EcoliWiki page
  6. Miller, CG & Schwartz, G (1978) Peptidase-deficient mutants of Escherichia coli. J. Bacteriol. 135 603-11 PubMed EcoliWiki page
  7. 7.0 7.1 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed EcoliWiki page
  8. Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed EcoliWiki page
  9. 9.0 9.1 9.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed EcoliWiki page
  10. 10.0 10.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed EcoliWiki page

Categories

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