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pepD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PepD

Synonyms

aminoacyl-histidine dipeptidase (peptidase D)[1], B0237[2][1], PepH[2][1]

Product description

PepD[2][3];

Component of peptidase D[3]

Peptidase D, Xaa-His dipeptidase[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0005515

protein binding

PMID:16606699[5]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6L9

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:16606699[5]

IPI: Inferred from Physical Interaction

UniProtKB:P0A8P3

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005737

cytoplasm

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [8]

complete

GO:0050897

cobalt ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0170

F

Seeded from EcoCyc [8]

complete

GO:0046983

protein dimerization activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011650

F

Seeded from EcoCyc [8]

complete

GO:0006508

proteolysis

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001160
InterPro:IPR002933

P

Seeded from EcoCyc [8]

complete

GO:0008233

peptidase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc [8]

complete

GO:0008237

metallopeptidase activity

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR002933
SP_KW:KW-0482

F

Seeded from EcoCyc [8]

complete

GO:0008270

zinc ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc [8]

complete

GO:0016787

hydrolase activity

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR011650
SP_KW:KW-0378

F

Seeded from EcoCyc [8]

complete

GO:0016805

dipeptidase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0224

F

Seeded from EcoCyc [8]

complete

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc [8]

complete

GO:0009050

glycopeptide catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0043171

peptide catabolic process

PMID:355237[9]

IGI: Inferred from Genetic Interaction

EcoliWiki:pepA EcoliWiki:pepB EcoliWiki:pepN EcoliWiki:pepQ


P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of peptidase D

could be indirect

Protein

dnaK

PMID:15690043[10]

Experiment(s):EBI-887128

Protein

pepP

PMID:15690043[10]

Experiment(s):EBI-887128, EBI-893231

Protein

wbbJ

PMID:16606699[5]

Experiment(s):EBI-1135989

Protein

greB

PMID:16606699[5]

Experiment(s):EBI-1135989

Protein

guaC

PMID:15690043[10]

Experiment(s):EBI-893231

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSELSQLSPQ PLWDIFAKIC SIPHPSYHEE QLAEYIVGWA KEKGFHVERD QVGNILIRKP
ATAGMENRKP VVLQAHLDMV PQKNNDTVHD FTKDPIQPYI DGEWVKARGT TLGADNGIGM
ASALAVLADE NVVHGPLEVL LTMTEEAGMD GAFGLQGNWL QADILINTDS EEEGEIYMGC
AGGIDFTSNL HLDREAVPAG FETFKLTLKG LKGGHSGGEI HVGLGNANKL LVRFLAGHAE
ELDLRLIDFN GGTLRNAIPR EAFATIAVAA DKVDVLKSLV NTYQEILKNE LAEKEKNLAL
LLDSVANDKA ALIAKSRDTF IRLLNATPNG VIRNSDVAKG VVETSLNVGV VTMTDNNVEI
HCLIRSLIDS GKDYVVSMLD SLGKLAGAKT EAKGAYPGWQ PDANSPVMHL VRETYQRLFN
KTPNIQIIHA GLECGLFKKP YPEMDMVSIG PTITGPHSPD EQVHIESVGH YWTLLTELLK
EIPAK
Length

485

Mol. Wt

52.916 kDa

pI

5.2 (calculated)

Extinction coefficient

47,900 - 48,400 (calc based on 10 Y, 6 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed

UniProt:P15288


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rectanglemotifs

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10695-MONOMER

UniProt (EcoliWiki Page)

UniProt:P15288

PFAM (EcoliWiki Page)

PFAM:PF07687

RefSeq (EcoliWiki Page)

RefSeq:NP_414772


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
  6. ↑ 6.0 6.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed EcoliWiki page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  9. ↑ Miller CG & Schwartz G (1978) Peptidase-deficient mutants of Escherichia coli. J Bacteriol 135: 603-11 PubMed EcoliWiki page
  10. ↑ 10.0 10.1 10.2 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page

Categories

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