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Standard Name


Gene Synonym(s)

ECK4366, b4375, JW5873, tos, miaD[1], sra, srb

Product Desc.

peptide chain release factor RF3[2][3]

Peptide chain release factor 3, RF-3; stimulates activity of RF-1 and RF-2[4]

Product Synonyms(s)

peptide chain release factor RF-3 [1], B4375 [2][1], Tos [2][1], MiaD [2][1], PrfC [2][1] , ECK4366, JW5873, sra, srb, tos, b4375

Function from GO
Knock-Out Phenotype

transcription unit(s): prfC[2]

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RF3 exits in two conformational states, state 1 which is a pre-translocation complex with a P-site tRNA and a pre-bound RF3 (inactive) while state 2 is a post-translocation conformation with RF3 tightly bound to the GTPase centre and the tRNA at the exit site. RF-3 is a class 2 RF, and a G-protein.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.