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purC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PurC

Synonyms

phosphoribosylaminoimidazole-succinocarboxamide synthetase[1], B2476[2][1], PurC[2][1]

Product description

PurC[2][3];

Component of phosphoribosylaminoimidazole-succinocarboxamide synthase[2][3]

Phosphoribosyl-aminoimidazole-succinocarboxamide synthase; purine synthesis[4]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0005515

protein binding

PMID:16606699[5]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6F5

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:16606699[5]

IPI: Inferred from Physical Interaction

UniProtKB:P0AF50

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005624

membrane fraction

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [8]

complete

GO:0016874

ligase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

Seeded from EcoCyc [8]

complete

GO:0006164

purine nucleotide biosynthetic process

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001636
SP_KW:KW-0658
HAMAP:MF_00137

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013816

F

Seeded from EcoCyc [8]

complete

GO:0004639

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

GO_REF:0000002
GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001636
EC:6.3.2.6
HAMAP:MF_00137

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013816

F

Seeded from EcoCyc [8]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005739

mitochondrion

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [8]

complete

GO:0005829

cytosol

PMID:16858726[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [8]

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of phosphoribosylaminoimidazole-succinocarboxamide synthase

could be indirect

Protein

dnaK

PMID:15690043[9]

Experiment(s):EBI-880319, EBI-885650

Protein

tig

PMID:15690043[9]

Experiment(s):EBI-880319, EBI-885650

Protein

cca

PMID:15690043[9]

Experiment(s):EBI-885650

Protein

evgA

PMID:15690043[9]

Experiment(s):EBI-885650

Protein

guaC

PMID:15690043[9]

Experiment(s):EBI-885650

Protein

lhr

PMID:15690043[9]

Experiment(s):EBI-885650

Protein

rplL

PMID:15690043[9]

Experiment(s):EBI-885650

Protein

yidZ

PMID:15690043[9]

Experiment(s):EBI-885650

Protein

groL

PMID:16606699[5]

Experiment(s):EBI-1142990

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MQKQAELYRG KAKTVYSTEN PDLLVLEFRN DTSAGDGARI EQFDRKGMVN NKFNYFIMSK
LAEAGIPTQM ERLLSDTECL VKKLDMVPVE CVVRNRAAGS LVKRLGIEEG IELNPPLFDL
FLKNDAMHDP MVNESYCETF GWVSKENLAR MKELTYKAND VLKKLFDDAG LILVDFKLEF
GLYKGEVVLG DEFSPDGSRL WDKETLEKMD KDRFRQSLGG LIEAYEAVAR RLGVQLD
Length

237

Mol. Wt

26.995 kDa

pI

4.9 (calculated)

Extinction coefficient

21,430 - 21,805 (calc based on 7 Y, 2 W, and 3 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences


Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:SAICARSYN-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P0A7D7

UniProt (EcoliWiki Page)

UniProt:P0A7D7

PFAM (EcoliWiki Page)

PFAM:PF01259

RefSeq (EcoliWiki Page)

RefSeq:NP_416971


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
  6. 6.0 6.1 6.2 6.3 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. 7.0 7.1 7.2 Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed EcoliWiki page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  9. 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed EcoliWiki page

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