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relE:Quickview

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Standard Name

relE

Gene Synonym(s)

ECK1557, b1563, JW1555[1], JW1555

Product Desc.

Qin prophage; toxin of the RelE-RelB toxin-antitoxin system[2][3]

Sequence-specific mRNA endoribonuclease, Qin prophage; toxin-antitoxin (TA) pair RelEB, RelE inhibitor of translation cleaves mRNA in A site; binds to its antitoxin RelB and to ribosomes; co-repressor of relB operon transcription; stress-induced[4]

Product Synonyms(s)

Qin prophage; toxin of the RelE-RelB toxin-antitoxin system[1], B1563[2][1], RelE[2][1] , ECK1557, JW1555, b1563

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): relE[2], relBE-hokD[3]

Regulation/Activity
Quick Links

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Notes

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Overproduction of RelE has been shown to increase persistance. Overexpression causes filamentous biofilm formation. Overexpression also reported to inhibit growth (Brown, 2003). Degraded by Lon protease.[4]



References

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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.