|Quickview||Gene||Gene Product(s)||Expression||Evolution||On One Page|
nudH, ECK2826, b2830, JW2798, ydgP, ygdP, ygdP
RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway); putative invasion protein RNA pyrophosphohydrolase, destabilizes primary transcripts
|Function from GO||
Many mRNAs have an increased half-life. 
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Nudix hydrolase. RppH removes 5' triphosphate from primary transcripts, enhancing RNase E activity (Deana, 2008). Required for invasion of cultured mammalian cells by both E. coli K1 and S. typhimurium. NudH also hydrolyzes Ap5A and Ap4A. Ribosome-associated protein (Jiang, 2007).
- Deana, A et al. (2008) The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal. Nature 451 355-8 PubMed EcoliWiki page
- Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.