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Standard Name


Gene Synonym(s)

ECK3329, b3342, JW3304, asuB, strA[1], strA

Product Desc.

30S ribosomal subunit protein S12[2][3];

Component of 30S ribosomal subunit[2][3]; ribosome[2][3]

30S ribosomal subunit protein S12; RNA chaperone[4]

Product Synonyms(s)

30S ribosomal subunit protein S12[1], B3342[2][1], StrA[2][1], AsuB[2][1], RpsL[2][1] , asuB, ECK3329, JW3304, strA, b3342

Function from GO

Cellular Component

Knock-Out Phenotype

transcription unit(s): rpsLG-fusA-tufA[2]

Quick Links

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See Help:Quickview for help with entering information in the Quickview table. RpsL is a ribosomal gene that encodes the highly conserved rps12 protein of the ribosomal accuracy center in the Escherichia coli. Numerous mutations in the rpsL gene generate resistance to, and in some instances dependence on, high levels of streptomycin. [5]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Toivonen, JM et al. (1999) Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL. Mol. Microbiol. 31 1735-46 PubMed EcoliWiki page

Mutations in regions 41-45 (except when lys42 is replaced with arg), 87-93 and 53 result in streptomycin resistance. A point mutation at 262 from A to G sustains protein synthesis in late stationary phase and increases the stability of the 70S complex in low magnesium concentrations.[1]
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