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rsmA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

RsmA

Synonyms

S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase[1], B0051[2][1], KsgA[2][1], RsmA[2][1]

Product description

S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase[2][3]

16S rRNA dimethyladenosine transferase; S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; mutant is kasugamycin resistant; multicopy suppressor of era(Cs)[4]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0000154

rRNA modification

GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001737
HAMAP:MF_00607

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0000179

rRNA (adenine-N6,N6-)-dimethyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001737

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0003723

RNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0694

F

Seeded from EcoCyc [6]

complete

GO:0006364

rRNA processing

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR011530
SP_KW:KW-0698

P

Seeded from EcoCyc [6]

complete

GO:0008168

methyltransferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0489

F

Seeded from EcoCyc [6]

complete

GO:0016433

rRNA (adenine) methyltransferase activity

GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR011530
HAMAP:MF_00607

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [6]

complete

GO:0046677

response to antibiotic

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0046
HAMAP:MF_00607

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0003690

double-stranded DNA binding

PMID:17890303[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [6]

complete

GO:0003729

mRNA binding

PMID:2500421[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [6]

complete

GO:0019843

rRNA binding

PMID:2500421[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [6]

complete

GO:0031167

rRNA methylation

PMID:4567337[9]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [6]

complete

GO:0009451

RNA modification

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0042493

response to drug

P

Seeded from EcoCyc 11.1[3].

required fields missing

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

murB

PMID:16606699[10]

Experiment(s):EBI-1135454

Protein

guaA

PMID:16606699[10]

Experiment(s):EBI-1135454

Protein

groL

PMID:16606699[10]

Experiment(s):EBI-1135454

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

cytoplasm

From EcoCyc[3]


Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MNNRVHQGHL ARKRFGQNFL NDQFVIDSIV SAINPQKGQA MVEIGPGLAA LTEPVGERLD
QLTVIELDRD LAARLQTHPF LGPKLTIYQQ DAMTFNFGEL AEKMGQPLRV FGNLPYNIST
PLMFHLFSYT DAIADMHFML QKEVVNRLVA GPNSKAYGRL SVMAQYYCNV IPVLEVPPSA
FTPPPKVDSA VVRLVPHATM PHPVKDVRVL SRITTEAFNQ RRKTIRNSLG NLFSVEVLTG
MGIDPAMRAE NISVAQYCQM ANYLAENAPL QES
Length

273

Mol. Wt

30.419 kDa

pI

8.1 (calculated)

Extinction coefficient

11,920 - 12,170 (calc based on 8 Y, W, and 2 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences


Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10523-MONOMER

UniProt (EcoliWiki Page)

UniProt:P06992

PFAM (EcoliWiki Page)

PFAM:PF00398

RefSeq (EcoliWiki Page)

RefSeq:NP_414593


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 5.3 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. Inoue K et al. (2007) Dissection of 16S rRNA methyltransferase (KsgA) function in Escherichia coli. J Bacteriol 189: 8510-8 PubMed EcoliWiki page
  8. 8.0 8.1 van Gemen B et al. (1989) Autogenous regulation of the Escherichia coli ksgA gene at the level of translation. J Bacteriol 171: 4002-8 PubMed EcoliWiki page
  9. Zimmermann RA et al. (1973) Alteration of ribosomal protein S4 by mutation linked to kasugamycin-resistance in Escherichia coli. Proc Natl Acad Sci U S A 70: 71-5 PubMed EcoliWiki page
  10. 10.0 10.1 10.2 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page

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