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References Suggestions

Standard Name


Gene Synonym(s)

ECK0099, b0098, JW0096, azi, pea, prlD[1], prlD

Product Desc.


Component of Sec Protein Secretion Complex[2][3]

Translocon ATPase; targets protein precursors to the SecYE core translocon for secretion; autogenous translational repressor; ATP-dependent helicase activity on secMA mRNA; homodimeric/monomeric[4]

Product Synonyms(s)

preprotein translocase subunit, ATPase[1], B0098[2][1], Pea[2][1], Azi[2][1], PrlD[2][1], SecA[2][1] , azi, ECK0099, JW0096, pea, prlD, b0098

Function from GO

Molecular Function

Cellular Component

Biological Process

Knock-Out Phenotype

transcription unit(s): secMA-mutT[2]

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Helicase activity is dispensable for both functions. Oligomerization induced by signal peptides. secA is regulated by the secretion competence of the SecM signal peptide. HT_Cmplx33_Cyt: AcpP+PurB+SecA. HT_Cmplx48_Mem: SecA+YdgA+YjiY.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.