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serB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SerB

Synonyms

3-phosphoserine phosphatase[1], B4388[2][1], SerB[2][1]

Product description

PSERPHOSPHA- Phosphoserine phosphatase; HAD9[3]

EC number (for enzymes)

Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

C

Seeded from EcoCyc 12.5 [4]

complete

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0006810

transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0006564

L-serine biosynthetic process

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004469
SP_KW:KW-0718

P

Seeded from EcoCyc 12.5 [4]

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0004647

phosphoserine phosphatase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR004469
EC:3.1.3.3

F

Seeded from EcoCyc 12.5 [4]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[5].

required fields missing

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005834

F

Seeded from EcoCyc [6]

complete

GO:0005515

protein binding

PMID:16606699[7]

IPI: Inferred from Physical Interaction

UniProtKB:P18843

F

Seeded from EcoCyc [6]

complete

GO:0008152

metabolic process

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005834
InterPro:IPR006383

P

Seeded from EcoCyc [6]

complete

GO:0008652

amino acid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0028

P

Seeded from EcoCyc [6]

complete

GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc [6]

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006383

F

Seeded from EcoCyc [6]

complete

GO:0006545

glycine biosynthetic process

P

Seeded from Riley et al 2006 [1].

required fields missing

GO:0006564

L-serine biosynthetic process

PMID:17012394[8]

IMP

P

Seeded from EcoCyc 11.1[5].

required fields missing

GO:0004647

phosphoserine phosphatase activity

PMID:16990279[9]

IDA

F

Seeded from EcoCyc 11.1[5].

required fields missing

GO:0006564

L-serine biosynthetic process

PMID:14086727[10]

IDA: Inferred from Direct Assay

P

complete

GO:0004647

phosphoserine phosphatase activity

PMID:14086727[10]

IDA: Inferred from Direct Assay

F

complete

GO:0005737

cytoplasm

PMID:14086727[10]

IDA: Inferred from Direct Assay

C

complete

GO:0008652

amino acid biosynthetic process

PMID:14086727[10]

IDA: Inferred from Direct Assay

P

complete

GO:0016791

phosphatase activity

PMID:14086727[10]

IDA: Inferred from Direct Assay

F

complete

GO:0000287

magnesium ion binding

PMID:14086727[10]

IDA: Inferred from Direct Assay

F

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1147974

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MPNITWCDLP EDVSLWPGLP LSLSGDEVMP LDYHAGRSGW LLYGRGLDKQ RLTQYQSKLG
AAMVIVAAWC VEDYQVIRLA GSLTARATRL AHEAQLDVAP LGKIPHLRTP GLLVMDMDST
AIQIECIDEI AKLAGTGEMV AEVTERAMRG ELDFTASLRS RVATLKGADA NILQQVRENL
PLMPGLTQLV LKLETLGWKV AIASGGFTFF AEYLRDKLRL TAVVANELEI MDGKFTGNVI
GDIVDAQYKA KTLTRLAQEY EIPLAQTVAI GDGANDLPMI KAAGLGIAYH AKPKVNEKAE
VTIRHADLMG VFCILSGSLN QK
Length

322

Mol. Wt

35.043 kDa

pI

5.6 (calculated)

Extinction coefficient

39,420 - 39,920 (calc based on 8 Y, 5 W, and 4 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences


Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:PSERPHOSPHA-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P0AGB0

UniProt (EcoliWiki Page)

UniProt:P0AGB0

PFAM (EcoliWiki Page)

PFAM:PF00702

RefSeq (EcoliWiki Page)

RefSeq:NP_418805


Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. 5.0 5.1 5.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. 6.0 6.1 6.2 6.3 6.4 6.5 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. 7.0 7.1 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed EcoliWiki page
  8. Joyce AR et al. (2006) Experimental and computational assessment of conditionally essential genes in Escherichia coli. J Bacteriol 188: 8259-71 PubMed EcoliWiki page
  9. Kuznetsova E et al. (2006) Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. J Biol Chem 281: 36149-61 PubMed EcoliWiki page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 PIZER LI (1963) THE PATHWAY AND CONTROL OF SERINE BIOSYNTHESIS IN ESCHERICHIA COLI. J Biol Chem 238: 3934-44 PubMed EcoliWiki page

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