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References Suggestions

Standard Name


Gene Synonym(s)

ECK3336, b3349, JW3311[1], JW3311

Product Desc.

FKBP-type rotamase, peptidyl prolyl cis-trans isomerase[2]; FKBP-type peptidyl prolyl cis-trans isomerase[3];

Component of FKBP-type peptidyl prolyl cis-trans isomerase[3]

FKBP-type peptidyl-prolyl cis-trans isomerase; metal ion regulated; overexpression causes filamentation; required to stabilize E lysis protein of bacteriophage phiX174[4]

Product Synonyms(s)

FKBP-type peptidyl prolyl cis-trans isomerase (rotamase)[1], B3349[2][1], SlyD[2][1], WHP[2][1] , ECK3336, JW3311, b3349

Function from GO

Molecular Function

Biological Process

Knock-Out Phenotype

transcription unit(s): slyD[2]

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HypB requires binding of SlyD for hydrogenase activity as SlyD helps facilitate nickel insertion. Binds TrxA (Kumar, 2004). SlyD has a histidine-rich, nickel-binding region, so it is a common contaminant in protein purification of His-tagged proteins (Parsy, 2007). SlyD is a a heat-shock protein that facilitates folding and enhances the solubilty of aggregation-prone proteins (Han, 2007).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.