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Standard Name

talB

Gene Synonym(s)

ECK0008, b0008, JW0007, yaaK[1]

Product Desc.

transaldolase B[2][3];

Component of transaldolase B[2][3]

Transaldolase B[4]

Product Synonyms(s)

transaldolase B[1], B0008[2][1], YaaK[2][1], TalB[2][1]

Function from GO

Cellular Component

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): talB[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(talB)    Textpresso(talB)

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Notes

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Binds TrxA (Kumar, 2004).[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

talB

Mnemonic

Transaldolase

Synonyms

ECK0008, b0008, JW0007, yaaK[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

0.18 minutes 

MG1655: 8238..9191
gbrowse_img.php?coord=8238..9191&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 8236..9189
gbrowse_img.php?coord=8236..9189&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 8238..9191
gbrowse_img.php?coord=8238..9191&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 8238..9191
gbrowse_img.php?coord=8238..9191&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 8238..9191
gbrowse_img.php?coord=8238..9191&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔtalB (Keio:JW0007)

deletion

deletion

PMID:16738554

Shigen
CGSC8338[5]

ΔtalB728::kan

PMID:16738554

CGSC:103082

Delta talA delta talB

deletion

deletion

Schneider et al. (2008) JBC 283, 3064-72

A. K. Samland, Institute of Microbiology, Universität Stuttgart


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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW0007

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCACGGACAAATTGACCTCCCT

Primer 2:CCCAGCAGATCGCCGATCATTTT

thrA34::Tn10

Linked marker

CAG18442 = CGSC7320[5]

est. P1 cotransduction: 76% [6]
Synonyms:thr-34::Tn10

carB96::Tn10

Linked marker

CAG12093 = CGSC7322[5]

est. P1 cotransduction: 40% [6]
Synonyms:car-96::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11556

EchoBASE (EcoliWiki Page)

EchoBASE:EB1517

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0008

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C0012

EcoGene (EcoliWiki Page)

EcoGene:EG11556

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:TALB

CGSC (EcoliWiki Page)

CGSC:36818

ASAP (EcoliWikiPage)

ASAP:ABE-0000027


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TalB

Synonyms

transaldolase B[1], B0008[2][1], YaaK[2][1], TalB[2][1]

Product description

transaldolase B[2][3];

Component of transaldolase B[2][3]

Transaldolase B[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [7]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013785

P

Seeded from EcoCyc [7]

complete

GO:0006098

pentose-phosphate shunt

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR004730
SP_KW:KW-0570
HAMAP:MF_00492

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001585

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0005737

cytoplasm

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004730
SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [8]

complete

GO:0004801

transaldolase activity

GO_REF:0000002
GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR004730
EC:2.2.1.2
HAMAP:MF_00492

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013785

F

Seeded from EcoCyc [7]

complete

GO:0005739

mitochondrion

PMID:16858726

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [7]

complete

GO:0005829

cytosol

PMID:16858726

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [7]

complete

GO:0009052

pentose-phosphate shunt, non-oxidative branch

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0004801

transaldolase activity

PMID:7592346

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 11.1[3].

complete

GO:0005624

membrane_fraction

PMID:16858726

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc 12.5 [8]

GO:0004801

transaldolase_activity

PMID:7592346

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [8]


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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

Subunits of transaldolase B

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes

Cytoplasm


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MTDKLTSLRQ YTTVVADTGD IAAMKLYQPQ DATTNPSLIL NAAQIPEYRK LIDDAVAWAK
QQSNDRAQQI VDATDKLAVN IGLEILKLVP GRISTEVDAR LSYDTEASIA KAKRLIKLYN
DAGISNDRIL IKLASTWQGI RAAEQLEKEG INCNLTLLFS FAQARACAEA GVFLISPFVG
RILDWYKANT DKKEYAPAED PGVVSVSEIY QYYKEHGYET VVMGASFRNI GEILELAGCD
RLTIAPALLK ELAESEGAIE RKLSYTGEVK ARPARITESE FLWQHNQDPM AVDKLAEGIR
KFAIDQEKLE KMIGDLL
Length

317

Mol. Wt

35.22 kDa

pI

4.9 (calculated)

Extinction coefficient

39,880 - 40,255 (calc based on 12 Y, 4 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences

Initiator Methionine

1

Removed

UniProt:P0A870

Modification Site

33

phosphorylation site at T33

probability less than 75%

PMID:17938405

Modification Site

34

phosphorylation site at T34

probability less than 75%

PMID:17938405

Modification Site

37

phosphorylation site at S37

probability greater than 75%

PMID:17938405

Modification Site

226

phosphorylation site at S226

probability greater than 75%

PMID:17938405

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:TRANSALDOLB-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A870

PFAM (EcoliWiki Page)

PFAM:PF00923

RefSeq (EcoliWiki Page)

RefSeq:NP_414549


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

talB

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=8218..8258&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b0008 (EcoliWiki Page)

NCBI GEO profiles for talB

microarray

GenExpDB:b0008 (EcoliWiki Page)

Summary of data for talB from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes

GFP Fusion

Intergenic region (7890..8316) fused to gfpmut2.

OpenBioSystems

GFP fusion described in Zaslaver, et al.
Plate:109-AZ02; Well:A2[9]

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Notes

Accessions Related to talB Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11556

EchoBASE (EcoliWiki Page)

EchoBASE:EB1517

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0008

EcoGene (EcoliWiki Page)

EcoGene:EG11556


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Anopheles gambiae

  • ENSANGP00000016323 (score: 1.000; bootstrap: 86%)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000004532 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT1G12230 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000013650 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Caenorhabditis briggsae

  • WBGene00024876 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Caenorhabditis elegans

  • WBGene00021286 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000009894 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000005728 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-030131-3277 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-040425-902 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-040425-901 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0231283 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0023477 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000008221 (score: 1.000; bootstrap: 100%)
  • ENSGALP00000007505 (score: 0.095)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000321259 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000009857 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000024536 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Mus musculus

  • MGI:1274789 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000005525 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000024863 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YLR354C (score: 1.000; bootstrap: 100%)
  • YGR043C (score: 0.391)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPCC10206c (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000129123 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00018137001 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000003513 (score: 1.000; bootstrap: 92%)

From Inparanoid:20070104

Shigella flexneri

TALB

From SHIGELLACYC

E. coli O157

TALB

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00923


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Notes

TalB exhibits high similarity with the human transaldolase Taldo1. For a phylogenetic analysis of transaldolases see Samland and Sprenger (2009)Int. J. Biochem. Cell Biol.41, 1482-94.

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  9. ↑ Zaslaver A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat Methods 3: 623-8 PubMed EcoliWiki page

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