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thrC:On One Page

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Standard Name

thrC

Gene Synonym(s)

ECK0004, b0004, JW0003[1]

Product Desc.

threonine synthase [2][3]

Threonine synthase[4]

Product Synonyms(s)

threonine synthase[1], B0004[2][1], ThrC[2][1]

Function from GO

Biological Process

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): thrLABC[2], OP00248, thr, thrABC

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(thrC)    Textpresso(thrC)

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

thrC

Mnemonic

Threonine

Synonyms

ECK0004, b0004, JW0003[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

0.08 minutes 

MG1655: 3734..5020
gbrowse_img.php?coord=3734..5020&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 3733..5019
gbrowse_img.php?coord=3733..5019&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 3734..5020
gbrowse_img.php?coord=3734..5020&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 3734..5020
gbrowse_img.php?coord=3734..5020&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 3734..5020
gbrowse_img.php?coord=3734..5020&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔthrC (Keio:JW0003)

deletion

deletion

PMID:16738554

Shigen
CGSC8334[5]

thrC1001

CGSC:5877

ΔthrC724::kan

PMID:16738554

CGSC:103152


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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW0003

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCAAACTCTACAATCTGAAAGA

Primer 2:CCCTGATGATTCATCATCAATTT

thrA34::Tn10

Linked marker

CAG18442 = CGSC7320[5]

est. P1 cotransduction: 88% [6]
Synonyms:thr-34::Tn10

carB96::Tn10

Linked marker

CAG12093 = CGSC7322[5]

est. P1 cotransduction: 33% [6]
Synonyms:car-96::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11000

EchoBASE (EcoliWiki Page)

EchoBASE:EB0993

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0004

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C0005

EcoGene (EcoliWiki Page)

EcoGene:EG11000

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:THRC

CGSC (EcoliWiki Page)

CGSC:109

ASAP (EcoliWikiPage)

ASAP:ABE-0000012


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ThrC

Synonyms

threonine synthase[1], B0004[2][1], ThrC[2][1]

Product description

threonine synthase [2][3]

Threonine synthase[4]

EC number (for enzymes)

4.2.3.1[1]

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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0030170

pyridoxal phosphate binding

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000634
InterPro:IPR001926

F

Seeded from EcoCyc [7]

complete

GO:0016829

lyase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc [7]

complete

GO:0009088

threonine biosynthetic process

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR004450
SP_KW:KW-0791

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0008652

amino acid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0028

P

Seeded from EcoCyc [7]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001926

P

Seeded from EcoCyc [7]

complete

GO:0006520

amino acid metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000634

P

Seeded from EcoCyc [7]

complete

GO:0004795

threonine synthase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR004450
EC:4.2.3.1

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001926

F

Seeded from EcoCyc [7]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009088

threonine_biosynthesis

PMID:6316258

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc 12.5 [8]

GO:0004795

threonine_synthase_activity

PMID:6316258

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [8]

GO:0005515

protein_binding

PMID:16606699

IPI: Inferred from Physical Interaction

UniProtKB:P0A6M8

F

Seeded from EcoCyc 12.5 [8]


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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence

Protein

fusA

PMID:16606699

Experiment(s):EBI-1135301

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MKLYNLKDHN EQVSFAQAVT QGLGKNQGLF FPHDLPEFSL TEIDEMLKLD FVTRSAKILS
AFIGDEIPQE ILEERVRAAF AFPAPVANVE SDVGCLELFH GPTLAFKDFG GRFMAQMLTH
IAGDKPVTIL TATSGDTGAA VAHAFYGLPN VKVVILYPRG KISPLQEKLF CTLGGNIETV
AIDGDFDACQ ALVKQAFDDE ELKVALGLNS ANSINISRLL AQICYYFEAV AQLPQETRNQ
LVVSVPSGNF GDLTAGLLAK SLGLPVKRFI AATNVNDTVP RFLHDGQWSP KATQATLSNA
MDVSQPNNWP RVEELFRRKI WQLKELGYAA VDDETTQQTM RELKELGYTS EPHAAVAYRA
LRDQLNPGEY GLFLGTAHPA KFKESVEAIL GETLDLPKEL AERADLPLLS HNLPADFAAL
RKLMMNHQ
Length

428

Mol. Wt

47.114 kDa

pI

5.2 (calculated)

Extinction coefficient

29,910 - 30,410 (calc based on 9 Y, 3 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:THRESYN-MONOMER

UniProt (EcoliWiki Page)

UniProt:P00934

PFAM (EcoliWiki Page)

PFAM:PF00291

RefSeq (EcoliWiki Page)

RefSeq:NP_414545


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

thrLABC

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=3714..3754&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b0004 (EcoliWiki Page)

NCBI GEO profiles for thrC

microarray

GenExpDB:b0004 (EcoliWiki Page)

Summary of data for thrC from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes
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Notes

Accessions Related to thrC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11000

EchoBASE (EcoliWiki Page)

EchoBASE:EB0993

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0004

EcoGene (EcoliWiki Page)

EcoGene:EG11000


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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

OrganismHomologs (Statistics)Comments

Arabidopsis thaliana

  • AT4G29840 (score: 1.000; bootstrap: 100%)
  • AT1G72810 (score: 0.739)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000005725 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000011010 (score: 1.000; bootstrap: 59%)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000010207 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-051127-19 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-051127-11 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000012431 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000328525 (score: 1.000; bootstrap: 56%)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000026690 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000011995 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Mus musculus

  • MGI:2139347 (score: 1.000; bootstrap: 50%)

From Inparanoid:20070104

Oryza gramene

  • Q6L4H5 (score: 1.000; bootstrap: 100%)
  • Q8LJJ2 (score: 0.864)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000004007 (score: 1.000; bootstrap: 51%)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000008698 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YCR053W (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPAC9E96c (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000155654 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00025503001 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000004122 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

THRC

From SHIGELLACYC

E. coli O157

THRC

From ECOO157CYC

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Do-It-Yourself Web Tools

Notes

Families

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DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00291


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 8.2 8.3 8.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

Categories

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