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thyA:Quickview
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| Standard Name |
thyA |
|---|---|
| Gene Synonym(s) |
ECK2823, b2827, JW2795[1] |
| Product Desc. |
Component of thymidylate synthase[2][3] Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer[4] |
| Product Synonyms(s) |
thymidylate synthetase[1], B2827[2][1], ThyA[2][1], 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase[2][1] |
| Function from GO | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
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Notes
Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
