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References Suggestions

Standard Name


Gene Synonym(s)

ECK0430, b0436, JW0426[1], JW0426

Product Desc.

trigger factor; a molecular chaperone involved in cell division[2][3]

Trigger factor, protein folding chaperone; also peptidyl-prolyl cis-trans isomerase; interacts with nascent polypeptide chains[4]

Product Synonyms(s)

peptidyl-prolyl cis/trans isomerase (trigger factor)[1], B0436[2][1], Tig[2][1] , ECK0430, JW0426, b0436

Function from GO

Molecular Function

Cellular Component

Biological Process

Knock-Out Phenotype

transcription unit(s): tig[2]

Quick Links

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dnaK and tig mutants are synthetic lethal at 30 degrees C, however, no lethal effects are observed at 23 degrees C. Overproduction of GroEL/GroES at 30 degrees C supresses synthetic lethality.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.