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Standard Name


Gene Synonym(s)

ECK3701, b3708, JW3686, ind, tnaR[1]

Product Desc.


Component of TRYPTOPHAN-CPLX[2]

Tryptophanase, also has cysteine desulfhydrase activity; interconverts tryptophan and indole; also called L-tryptophan indole-lyase;[4]

Product Synonyms(s)

tryptophanase/L-cysteine desulfhydrase, PLP-dependent[1], B3708[2][1], Ind[2][1], TnaR[2][1], TnaA[2][1] , ECK3701, ind, JW3686, b3708

Function from GO
Knock-Out Phenotype

transcription unit(s): tnaCAB[2], OP00116, tna, tnaAB

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TnaA is required for growth on tryptophan as a carbon source and indole as a tryptophan source. TnaA is a key enzyme in L-cysteine degradation. Alkali-inducible. Downregulated during cold-shock and in early exponential phase. Binds TrxA (Kumar, 2004). TnaA binds plasmid colE1 sRNA Rcd, which modulates TnaA activity to regulate growth inhibition by Rcd for plasmid stabilzation (Chant, 2003).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.