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torS:On One Page

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Standard Name

torS

Gene Synonym(s)

ECK0984, b0993, JW5135, yccI[1]

Product Desc.

TorS-Phis850, TorS-Pasp723 [2][3]

Sensor kinase for torCAD operon[4]

Product Synonyms(s)

hybrid sensory histidine kinase in two-component regulatory system with TorR[1],

B0993[2][1],

YccI[2][1],

sensor kinase-phosphotransferase TorS-Phis850[2][1],

phospho-TorS-his850[2][1],

phosphorylated sensor kinase-phosphotransferase TorS[2][1],

modified sensor kinase-phosphotransferase TorS[2][1]

Function from GO
Knock-Out Phenotype
Regulation/Expression

transcription unit(s): torS[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(torS)    Textpresso(torS)

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

torS

Mnemonic

Trimethylamine oxide reductase

Synonyms

ECK0984, b0993, JW5135, yccI[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

StrainMap locationGenome coordinatesGenome browsersSequence links

MG1655

22.69 minutes 

MG1655: 1055401..1052657
gbrowse_img.php?coord=1052657..1055401&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 1072468..1069724
gbrowse_img.php?coord=1069724..1072468&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 1056600..1053856
gbrowse_img.php?coord=1053856..1056600&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 1109329..1106585
gbrowse_img.php?coord=1106585..1109329&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

BW2952

NC_012759: 955625..958369
gbrowse_img.php?coord=955625..958369&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature typeLocationDescription
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

AlleleNt change(s)AA change(s)Phenotype: TypePhenotype: DescriptionReferenceAvailabilityComments

ΔtorS (Keio:JW5135)

deletion

deletion

PMID:16738554

Shigen

torSH453Q

H453Q

Loss of activity

seeded from UniProt:P39453

torS

Deletion

torSH408L

H408L

(in torS729; partial activation)

Strain variation; seeded from UniProt:P39453

torSA414P

A414P

(in torS13; partial activation)

Strain variation; seeded from UniProt:P39453

torSD733A,E

D733A,E

Loss of activity

seeded from UniProt:P39453

torSH860Q

H860Q

Decrease in activity

seeded from UniProt:P39453

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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

ResourceResource TypeSourceNotes/Reference

JW5135

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCAATTTAACCCTGACCCGAAG

Primer 2:CCAATCGCGTTCAGGTCTTTCTT

zcb-3059::Tn10

Linked marker

CAG12094 = CGSC7358[5]

est. P1 cotransduction: 9% [6]

zcc-282::Tn10

Linked marker

CAG18466 = CGSC7359[5]

est. P1 cotransduction: 71% [6]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G6514

EchoBASE (EcoliWiki Page)

EchoBASE:EB2501

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0993

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C1128

EcoGene (EcoliWiki Page)

EcoGene:EG12617

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:TORS

ASAP (EcoliWikiPage)

ASAP:ABE-0003354


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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TorS

Synonyms

hybrid sensory histidine kinase in two-component regulatory system with TorR[1],

B0993[2][1],

YccI[2][1],

sensor kinase-phosphotransferase TorS-Phis850[2][1],

phospho-TorS-his850[2][1],

phosphorylated sensor kinase-phosphotransferase TorS[2][1],

modified sensor kinase-phosphotransferase TorS[2][1]

Product description

TorS-Phis850, TorS-Pasp723 [2][3]

Sensor kinase for torCAD operon[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology

TorS

See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus

GO:0018106

peptidyl-histidine phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005467

P

Seeded from EcoCyc [7]

complete

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004358

F

Seeded from EcoCyc [7]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [7]

complete

GO:0016310

phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004358

P

Seeded from EcoCyc [7]

complete

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

Seeded from EcoCyc [7]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [8]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003660
InterPro:IPR003661
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [8]

complete

GO:0007165

signal transduction

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003660
InterPro:IPR003661
InterPro:IPR009082

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

P

Seeded from EcoCyc [7]

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003594

F

Seeded from EcoCyc [7]

complete

GO:0004871

signal transducer activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003660
InterPro:IPR009082

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0004673

protein histidine kinase activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR005467
EC:2.7.13.3

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001789
SP_KW:KW-902

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0000156

two-component response regulator activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

F

Seeded from EcoCyc [7]

complete

GO:0000155

two-component sensor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003661

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0006464

protein modification process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [7]

complete

GO:0016485

protein processing

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009061

anaerobic respiration

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions

TorS

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner TypePartnerNotesReferencesEvidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

CompartmentDescriptionEvidenceSourceNotes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MGFALMALLT LTSTLVGWYN LRFISQVEKD NTQALIPTMN MARQLSEASA WELFAAQNLT
SADNEKMWQA QGRMLTAQSL KINALLQALR EQGFDTTAIE QQEQEISRSL RQQGELVGQR
LQLRQQQQQL SQQIVAAADE IARLAQGQAN NATTSAGATQ AGIYDLIEQD QRQAAESALD
RLIDIDLEYV NQMNELRLSA LRVQQMVMNL GLEQIQKNAP TLEKQLNNAV KILQRRQIRI
EDPGVRAQVA TTLTTVSQYS DLLALYQQDS EISNHLQTLA QNNIAQFAQF SSEVSQLVDT
IELRNQHGLA HLEKASARGQ YSLLLLGMVS LCALILILWR VVYRSVTRPL AEQTQALQRL
LDGDIDSPFP ETAGVRELDT IGRLMDAFRS NVHALNRHRE QLAAQVKART AELQELVIEH
RQARAEAEKA SQAKSAFLAA MSHEIRTPLY GILGTAQLLA DNPALNAQRD DLRAITDSGE
SLLTILNDIL DYSAIEAGGK NVSVSDEPFE PRPLLESTLQ LMSGRVKGRP IRLATAIADD
MPCALMGDPR RIRQVITNLL SNALRFTDEG YIILRSRTDG EQWLVEVEDS GCGIDPAKLA
EIFQPFVQVS GKRGGTGLGL TISSRLAQAM GGELSATSTP EVGSCFCLRL PLRVATAPVP
KTVNQAVRLD GLRLLLIEDN PLTQRITIEM LKTSGAQIVA VGNAAQALET LQNSEPFAAA
LVDFDLPDID GITLARQLAQ QYPSLVLIGF SAHVIDETLR QRTSSLFRGI IPKPVPREVL
GQLLAHYLQL QVNNDQSLDV SQLNEDAQLM GTEKIHEWLV LFTQHALPLL DEIDIARASQ
DSEKIKRAAH QLKSSCSSLG MHIASQLCAQ LEQQPLSAPL PHEEITRSVA ALEAWLHKKD LNAI
Length

904

Mol. Wt

99.741 kDa

pI

6.1 (calculated)

Extinction coefficient

56,380 - 57,255 (calc based on 12 Y, 7 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

TypeResiduesDescriptionNotesReferences
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tmhmm.php?gene=torS&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures
Models

View models at:

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Structure figures

Notes

Gene Product Resources

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Resource typeSourceNotes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:TORS-MONOMER

UniProt (EcoliWiki Page)

UniProt:P39453

PFAM (EcoliWiki Page)

PFAM:PF00672

RefSeq (EcoliWiki Page)

RefSeq:NP_415513


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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

MoleculeOrganism or StrainCellular levelUnitsMediumTemperature °COther (e.g. anaerobic)Growth rateAssay usedNotesReference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

torS

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Figure courtesy of RegulonDB

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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gbrowse_img.php?coord=1055381..1055421&genome=ecoli&name=MG1655&trackset=Gene+DNA_+Protein+flip&width=400&figure=Nterm&.png
This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele NameMutationPhenotypeReference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

TypeReferenceNotes

microarray

GEO Profiles:b0993 (EcoliWiki Page)

NCBI GEO profiles for torS

microarray

GenExpDB:b0993 (EcoliWiki Page)

Summary of data for torS from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource NameResource TypeDescriptionSourceNotes

GFP Fusion

Intergenic region (1055296..1055542) fused to gfpmut2.

OpenBioSystems

GFP fusion described in Zaslaver, et al.
Plate:109-AZ04; Well:B1[9]

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Notes

Accessions Related to torS Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

EcoCyc (EcoliWiki Page)

EcoCyc:G6514

EchoBASE (EcoliWiki Page)

EchoBASE:EB2501

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0993

EcoGene (EcoliWiki Page)

EcoGene:EG12617


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Notes

Links

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Evolution

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Homologs in Other Organisms

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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

DatabaseAccessionNotes

PFAM (EcoliWiki Page)

PFAM:PF00672


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  9. ↑ Zaslaver A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat Methods 3: 623-8 PubMed EcoliWiki page

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