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References Suggestions

Standard Name


Gene Synonym(s)

trmE, ECK3699, b3706, JW3684, thdF, o454[1][2][3]

Product Desc.

GTP-binding protein with a role in modification of tRNA[3][2]

5-methylaminomethyl-2-thiouridine modification at tRNA U34; cmnm(5) addition to tRNA-s(2)U34, forming (with subsequent or interdependent MnmG action) cmnm(5)s(2)U34-tRNA, an intermediate in mnm(5)s(2)U34-tRNA synthesis[4]

Product Synonyms(s)

GTPase[1], B3706[3][1], MnmE[3][1], TrmE[3][1], ThdF[3][1], O454[3][1] , ECK3699, JW3684, thdF, trmE, b3706

Function from GO
Knock-Out Phenotype

transcription unit(s): trmE[3]

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GTPase activity is essential for modification function. Mutants are hypomodified for s(2)U34 in tRNA(Lys). The carboxymethylaminomethyl donor is unknown. U34 is the wobble base.mnmE has proposed to be epistatic to mnmG, preceding it in the pathway (Bregeon, 2001), but Yim (2000) suggest that the MnmE and MnmG activities are interdependent, not sequential. MnmG(GidA) and MnmE form a heterotetrameric complex (Yim, 2006).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.