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Standard Name


Gene Synonym(s)

ECK2312, b2318, JW2315, asuC, hisT, leuK[1], leuK

Product Desc.

tRNA pseudouridine synthase I[2][3]

tRNA pseudouridine synthase specific to U38, U39, U40; mutations derepress his operon attenuator[4]

Product Synonyms(s)

pseudouridylate synthase I[1], B2318[2][1], LeuK[2][1], HisT[2][1], AsuC[2][1], TruA[2][1] , asuC, ECK2312, hisT, JW2315, leuK, b2318

Function from GO
Knock-Out Phenotype

transcription unit(s): usg-truA-dedA[2], pdxB-usg-truA-dedA[2]

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First identified as hisT, a his operon regulatory mutation, due to its effects on the his attenuator; pleiotropic phenotypes; mutant form causes translation errors[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.