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uup:Quickview

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Standard Name

uup

Gene Synonym(s)

ECK0940, b0949, JW0932, ycbH, ycbI, tex[1][2]

Product Desc.

ATP-binding protein with possible role in replication[2][3]

DNA-binding ATPase involved in replication; cytosolic; mutant displays an increased frequency of precise excision of transposons and defective growth of bacteriophage Mu[4]

Product Synonyms(s)

fused predicted transporter subunits of ABC superfamily: ATP-binding components[1], B0949[2][1], YcbH[2][1], YcbI[2][1], Uup[2][1], Tex[2][1] , ECK0940, JW0932, ycbH, ycbI, b0949

Function from GO

Molecular Function

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): rlmL-uup[2]

Regulation/Activity
Quick Links

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Notes

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Has two ABC ATPase domains; ATPase activity is essential for function. A C-terminal domain of the protein displays predicted structural homology with the Little Finger domain of Y family DNA polymerases and is involved in DNA binding.[4]

Similar to yeast proteins involved in ribosomal function and assembly.





References

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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.