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References Suggestions

Standard Name


Gene Synonym(s)

ECK2110, b4541, JW2106[1], JW2106

Product Desc.

predicted protein[2][3]

Function unknown, very hypothetical[4]

Product Synonyms(s)

predicted protein[1], YehK[2][1], B4541[2][1] , ECK2110, JW2106, b4541

Function from GO
Knock-Out Phenotype

transcription unit(s): yehK[2]

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YehK has no homologs and is polymorphic in E. coli and Shigella strains with many truncated versions and the presence of in frame stop codons. This is an indication that yehK is not really a protein-coding gene and it will likely be removed from EcoGene in the near future. yehK was not originally annotated as a gene (Blattner, 1997) but was added later based on a GeneMark.hmm 2.4 prediction of an atypical protein coding region. An insertion in a version of yehK in EPEC E. coli blocks interference with host functions, but may be affecting the downstream gene yehL (Nadler, 2006).[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.