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References Suggestions

Standard Name


Gene Synonym(s)

yhhP, ECK3454, b3470, JW3435, tusA[1][2][3], sirA, tusA

Product Desc.

sulfur transfer protein[3][2]

2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis; motility defect; affects RpoS stability; may bind RNA; mutants form filaments dues to disruption of ftsZ ring; suppressed by multicopy ftsZ or dksA; required for cell growth[4]

Product Synonyms(s)

conserved protein required for cell growth[1], B3470[3][1], YhhP[3][1], SirA[3][1], TusA[3][1] , TusA, ECK3454, JW3435, tusA, yhhP, b3470

Function from GO
Knock-Out Phenotype

transcription unit(s): tusA[3]

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SirA(TusA) interacts with and activates IscS, accepting sulfur from IscS to form C19 persulfide; transfers C19 persulfide to C78 of YheN(TusD). The gene name tus has already been used as a primary gene name, so tusA-E are kept as synonyms in EcoGene.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.