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References Suggestions

Standard Name


Gene Synonym(s)

ECK3510, b3525, JW3493[1], JW3493

Product Desc.

protein involved in flagellar function[2][3]

Cyclic-di-GMP phosphodiesterase, FlhDC-regulated; suppresses motility defect of hns mutants in multicopy[4]

Product Synonyms(s)

EAL domain containing protein involved in flagellar function[1], B3525[2][1], YhjH[2][1] , ECK3510, JW3493, b3525

Function from GO

Biological Process

Molecular Function

Knock-Out Phenotype

transcription unit(s): yhjH[2]

Quick Links

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Overexpressed Salmonella typhimurium YhjH (STM3611) enhances motitility, counteracts cellulose biosynthesis and the rdar phenotype, and mediates cyclic-di-GMP degradation. YhjH contains a putative cyclic-di-GMP phosphodiesterase EAL domain. The increased motility of the hns supppressing E. coli yhjH clones is consistent with the model that low cyclic di-GMP favors motility over sessility. FlhDC flagellar regulon. YhjH also contains a domain homologous to the methionine-tRNA ligase dimerization appendix. yhjH mutants have reduced swimming motility, dependent on ycgR and yegE: a null ycgR mutation fully suppress the yhjH motility defect; a null yegE mutation partially suppresses yhjH; a null yedQ mutation barely suppresses yhjH; a null ydaM mutation does not suppress yhjH (Figure 3A) (Pesavento, 2008).[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.