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yqhD:Quickview

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References Suggestions

Standard Name

yqhD

Gene Synonym(s)

ECK3003, b3011, JW2978[1], JW2978

Product Desc.

NADP-dependent alcohol dehydrogenase[2][3]

Aldehyde reductase, protects against lipid oxidation; NADPH-dependent; contains Zn; homodimer[4]

Product Synonyms(s)

alcohol dehydrogenase, NAD(P)-dependent[1], B3011[2][1], YqhD[2][1] , ECK3003, JW2978, b3011

Function from GO

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yqhD[2]

Regulation/Activity
Quick Links

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Notes

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AFMB Structural Genomics target No. 57 (http://afmb.cnrs-mrs.fr/article171.html). HT_Cmplx40_Cyt: YbgI+YqhD. YqhD is induced under conditions that favor lipid oxidation; overexpression increases resistance to paraquat, hydrogen peroxide and the lipid peroxidation-derived aldehydes butanaldehyde, propanaldehyde, acrolein and malondialdehyde; yqhD mutants are senstive to paraquat and hydrogen peroxide (Perez, 2008). YqhD catalyzes the NADPH-dependent reduction of acetaldehyde, malondialdehyde, propanaldehyde, butanaldehyde and acrolein in vitro (Perez, 2008). YqhD was reported to have no aldehyde dehydrogenase activity and to have in vitro alcohol dehydrogenase activity with a preference for alcohols longer than C3(Sulzenbacher , 2004), however these results are contradicted by Perez (2009).[4]



References

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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.