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References Suggestions

Standard Name


Gene Synonym(s)

ECK4205, b4209, JW4167[1], dnrN, JW4167

Product Desc.

iron metabolism protein[2]; protein involved in repair of stress-damaged iron-sulfur clusters[3]

Iron-sulfur cluster repair protein; confers resistance to nitric oxide and hydrogen peroxide; di-iron center[4]

Product Synonyms(s)

predicted regulator of cell morphogenesis and cell wall metabolism[1], B4209[2][1], YtfE[2][1] , dnrN, ECK4205, JW4167, b4209

Function from GO
Knock-Out Phenotype

transcription unit(s): ytfE[2]

Quick Links

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ytfE is induced by NO as part of the NsrR regulon. YtfE can regenerate damaged AcnB and FumA in vitro (Justino, 2007). A ytfE mutant grows poorly under anaerobic respiratory conditions and has an increased sensitivity to iron starvation. ytfE is homologous to S. aureus scdA. ytfE expression is increased in fnr and fur mutants, but no obvious Fnr or Fur binding sites were found.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.