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Browse and analyze data from Al Mamun et al. (Science 2012) Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks 338:1344-1348

This dataset of 93 genes was constructed by screening E. coli for mutants deficient in mutagenic repair of DNA breaks under stress, followed by secondary screens for genes that participate in activation of stress responses. This study identifies a network of genes involved in stress-induced mutagenesis (the SIM Network). This data browser allows you to examine the classification of SIM network genes and explore the data from different assays on individual network genes. You can also download excel versions of the supplemental tables from the paper.

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All SIM Network Genes

ClassStress-induced mutagenesis-deficient mutant genes
Cellular processesacrA
Cellular processesacrB
UnknownapaG
MetabolismapaH
RegulatorsarcA
MetabolismargD
RegulatorsargR
RegulatorsbarA
Regulatorscrp
Chaperones and proteasescspC
RegulatorscyaA
Electron transfercyoA
Electron transfercyoD
MetabolismcysD
DNA replication and repairdinB
Cellular processesdsbA
Cellular processesdsbC
Electron transferfre
RegulatorsfruR
RegulatorsglnK
Chaperones and proteasesgroES
RegulatorshdfR
Electron transferhemL
Chaperones and proteaseshfq
Electron transferhscB
RegulatorsihfA
Chaperones and proteasesldcA
RegulatorslexA
DNA replication and repair-relatedligA
MetabolismlipB
Chaperones and proteaseslon
Regulatorslrp
RegulatorsmalI
Electron transfermdh
RegulatorsmetJ
RegulatorsnagC
Electron transfernuoC
Electron transfernuoG
Electron transfernuoH
Electron transfernuoJ
Electron transfernuoK
Electron transfernuoL
RegulatorsnusA
Chaperones and proteasespepP
Electron transferpgi
Metabolismpgl
RegulatorsphoU
DNA replication and repairpolB
Regulatorsppk
Chaperones and proteasesprc
Cellular processesproL
Cellular processespstB
Cellular processespstC
MetabolismrbsK
DNA replication and repairrecA
DNA replication and repairrecB
DNA replication and repairrecC
DNA replication and repairrecF
RegulatorsrpoE
RegulatorsrpoS
Cellular processesrppH
DNA replication and repairruvA
DNA replication and repairruvB
DNA replication and repairruvC
Electron transfersdhB
Electron transfersdhD
MetabolismspeD
MetabolismspeE
Cellular processessrlA
DNA replication and repairsulA
Cellular processestatC
RegulatorstreR
Cellular processestrxB
Electron transferubiA
Electron transferubiD
Electron transferubiE
Electron transferubiH
Electron transferubiX
DNA replication and repairumuC
RegulatorsuvrY
UnknownybjT
UnknownyfjL
UnknownygfA
UnknownyhhK
UnknownyicC
UnknownyifE
UnknownyigP
UnknownyjcC
UnknownyqgE
UnknownyqiC
UnknownytjB
Cellular processesznuA
Cellular processesznuC
ClassStress-induced mutagenesis-deficient mutant genes

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Excel versions of supplemental tables: